Reduced fertility in mice deficient for the POU protein sperm-1

Richard V. Pearse, Daniel W. Drolet, Kristin A. Kalla, Farideh Hooshmand, John R. Bermingham, Michael G. Rosenfeld

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm 1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell.

Original languageEnglish
Pages (from-to)7555-7560
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number14
StatePublished - Jul 8 1997


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