Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature

Micah K. Harris; Margaret Shatara; Zachary Funk; Joseph Stanek; Daniel R. Boué; Jeremy Jones; Jonathan L. Finlay; Mohamed S. Abdelbaki

doi:10.1007/s00381-021-05197-6

Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature

Micah K. Harris, Margaret Shatara, Zachary Funk, Joseph Stanek, Daniel R. Boué, Jeremy Jones, Jonathan L. Finlay, Mohamed S. Abdelbaki

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Abstract

Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.

Original language	English
Pages (from-to)	465-472
Number of pages	8
Journal	Child's Nervous System
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s00381-021-05197-6
State	Published - Feb 2022

Keywords

CTNNB1
Case report
Marrow-ablative chemotherapy
Medulloblastoma
Recurrent
Wnt

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10.1007/s00381-021-05197-6

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Harris, M. K., Shatara, M., Funk, Z., Stanek, J., Boué, D. R., Jones, J., Finlay, J. L., & Abdelbaki, M. S. (2022). Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Child's Nervous System, 38(2), 465-472. https://doi.org/10.1007/s00381-021-05197-6

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abstract = "Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.",

keywords = "CTNNB1, Case report, Marrow-ablative chemotherapy, Medulloblastoma, Recurrent, Wnt",

author = "Harris, {Micah K.} and Margaret Shatara and Zachary Funk and Joseph Stanek and Bou{\'e}, {Daniel R.} and Jeremy Jones and Finlay, {Jonathan L.} and Abdelbaki, {Mohamed S.}",

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AU - Stanek, Joseph

AU - Boué, Daniel R.

AU - Jones, Jeremy

AU - Finlay, Jonathan L.

AU - Abdelbaki, Mohamed S.

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AB - Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.

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Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature

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Keywords

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