Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma

Michael G. Fradley, John D. Groarke, Jacob Laubach, Melissa Alsina, Daniel J. Lenihan, Robert F. Cornell, Michelle Maglio, Kenneth H. Shain, Paul G. Richardson, Javid Moslehi

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Patients with multiple myeloma (MM) have improved treatment options, including immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). Despite their efficacy, increased rates of cardiovascular (CV) complications occur in patients exposed to some of these therapies. While previous research has focused on identifying the toxicities inherent to each specific agent, the CV side effects may be potentiated by the combination of PIs and IMiDs plus dexamethasone. We present a patient with MM with recurrent cardiotoxicity only when exposed to combination PI and IMiD-based therapy. We also review the literature in this context, and propose a potential algorithm for cardiotoxicity prevention in this population.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalBritish Journal of Haematology
Volume180
Issue number2
DOIs
StatePublished - Jan 2018

Keywords

  • cardio-oncology
  • cardiotoxicity
  • immunomodulatory drugs
  • multiple myeloma
  • proteasome inhibitor

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    Fradley, M. G., Groarke, J. D., Laubach, J., Alsina, M., Lenihan, D. J., Cornell, R. F., Maglio, M., Shain, K. H., Richardson, P. G., & Moslehi, J. (2018). Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma. British Journal of Haematology, 180(2), 271-275. https://doi.org/10.1111/bjh.14970