Recurrence patterns after resection of retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative

Konstantinos Chouliaras, Rebecca Senehi, Cecilia G. Ethun, George Poultsides, Thuy Tran, Valerie Grignol, Thomas Clark Gamblin, Kevin K. Roggin, Jennifer Tseng, Ryan C. Fields, Sharon M. Weber, Gregory B. Russell, Edward A. Levine, Kenneth Cardona, Konstantinos Votanopoulos

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background and Objectives: Resection of primary retroperitoneal sarcomas (RPS) has a high incidence of recurrence. This study aims to identify patterns of recurrence and its impact on overall survival. Methods: Adult patients with primary retroperitoneal soft tissue sarcomas who underwent resection in 2000-2016 at eight institutions of the US Sarcoma Collaborative were evaluated. Results: Four hundred and ninety-eight patients were analyzed, with 56.2% (280 of 498) having recurrences. There were 433 recurrences (1-8) in 280 patients with 126 (25.3%) being locoregional, 82 (16.5%) distant, and 72 (14.5%) both locoregional and distant. Multivariate analyses revealed the following: Patient age P =.0002), tumor grade (P =.02), local recurrence (P =.0003) and distant recurrence (P <.0001) were predictors of disease-specific survival. The 1-, 3-, and 5-year survival rate for patients who recurred vs not was 89.6% (standard error [SE] 1.9) vs 93.5% (1.8), 66.0% (3.2) vs 88.4% (2.6), and 51.8% (3.6) vs 83.9% (3.3), respectively, P <.0001. Median survival was 5.3 years for the recurrence vs 11.3+ years for the no recurrence group (P <.0001). Median survival from the time of recurrence was 2.5 years. Conclusions: Recurrence after resection of RPS occurs in more than half of patients independently of resection status or perioperative chemotherapy and is equally distributed between locoregional and distant sites. Recurrence is primarily related to tumor biology and is associated with a significant decrease in overall survival.

Original languageEnglish
Pages (from-to)340-347
Number of pages8
JournalJournal of surgical oncology
Volume120
Issue number3
DOIs
StatePublished - Sep 2019

Keywords

  • distant relapse
  • local relapse
  • overall survival
  • predictors

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