Recurrence of bilateral diffuse bronchiectasis after bilateral lung transplantation

Fengshi Chen, Seiki Hasegawa, Toru Bando, Masanori Kitaichi, Takuya Hiratsuka, Masahiro Kawashima, Nobuharu Hanaoka, Takashi Yoshimura, Fumihiro Tanaka, Elbert P. Trulock, Hiromi Wada

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4 Scopus citations

Abstract

We report two cases of bilateral diffuse bronchiectasis in which early recurrence of the original lung disease occurred after bilateral lung transplantation (LT). Patient 1 underwent cadaveric LT. Recurrent bronchiectasis occurred 4 months later, and he died 6 years after LT. Patient 2 underwent living-related lobar LT, bronchiectasis relapsed 4 months later, and he died 13 months after LT. Both cases were finally diagnosed as bilateral diffuse bronchiectasis by the pathological features of the explanted lungs: infiltration of inflammatory cells predominantly in the conducting airways with dilation of the bronchi of bilateral lungs and scarcity of foamy macrophages in the wall of the respiratory bronchioles. Similar pathological features were seen in autopsy specimens from patient 1 and a transbronchial biopsy specimen from patient 2. LT should be carried out with caution in patients with bilateral diffuse bronchiectasis. When performing LT in such patients, it is suggested that sinusitis should be controlled perioperatively.

Original languageEnglish
Pages (from-to)666-668
Number of pages3
JournalRespirology
Volume11
Issue number5
DOIs
StatePublished - Sep 1 2006

Keywords

  • Bronchiectasis
  • Diffuse panbrochiolitis
  • Lung transplantation
  • Recurrence

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    Chen, F., Hasegawa, S., Bando, T., Kitaichi, M., Hiratsuka, T., Kawashima, M., Hanaoka, N., Yoshimura, T., Tanaka, F., Trulock, E. P., & Wada, H. (2006). Recurrence of bilateral diffuse bronchiectasis after bilateral lung transplantation. Respirology, 11(5), 666-668. https://doi.org/10.1111/j.1440-1843.2006.00904.x