TY - JOUR
T1 - Recueil des Travaux Chimiques des Pays‐Bas Journal of the Royal Netherlands Chemical Society
T2 - General method for the synthesis of 3′,5′‐diesters and 2′‐acetals of the four common nucleosides
AU - van Boom, J. H.
AU - Burgers, P. M.J.
AU - Haasnoot, C. A.G.
AU - Reese, C. B.
PY - 1977
Y1 - 1977
N2 - A procedure suitable for the preparation on a large scale of 5′‐O‐(methoxyacetyl)‐3′‐O‐propionylribonucleosides (9a‐d) from each of the four main ribonucleosides 6a‐d has been developed. The usefulness of 9a‐d as starting products for the synthesis of crystalline 2′‐O‐(methoxytetrahydropyranyl)‐ribonucleosides (11a‐d), which are key intermediates in the synthesis of oligoribonucleotides, has been demonstrated.
AB - A procedure suitable for the preparation on a large scale of 5′‐O‐(methoxyacetyl)‐3′‐O‐propionylribonucleosides (9a‐d) from each of the four main ribonucleosides 6a‐d has been developed. The usefulness of 9a‐d as starting products for the synthesis of crystalline 2′‐O‐(methoxytetrahydropyranyl)‐ribonucleosides (11a‐d), which are key intermediates in the synthesis of oligoribonucleotides, has been demonstrated.
UR - http://www.scopus.com/inward/record.url?scp=84917993720&partnerID=8YFLogxK
U2 - 10.1002/recl.19770960402
DO - 10.1002/recl.19770960402
M3 - Article
AN - SCOPUS:84917993720
SN - 0165-0513
VL - 96
SP - 91
EP - 95
JO - Recueil des Travaux Chimiques des Pays‐Bas
JF - Recueil des Travaux Chimiques des Pays‐Bas
IS - 4
ER -