Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

Katharine Michelle Ng; Andrés Aranda-Díaz; Carolina Tropini; Matthew Ryan Frankel; William Van Treuren; Colleen T. O'Laughlin; Bryan Douglas Merrill; Feiqiao Brian Yu; Kali M. Pruss; Rita Almeida Oliveira; Steven Kyle Higginbottom; Norma F. Neff; Michael Andrew Fischbach; Karina Bivar Xavier; Justin Laine Sonnenburg; Kerwyn Casey Huang

doi:10.1016/j.chom.2019.10.011

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

Katharine Michelle Ng
, Andrés Aranda-Díaz
, Carolina Tropini
, Matthew Ryan Frankel
, William Van Treuren
, Colleen T. O'Laughlin
, Bryan Douglas Merrill
, Feiqiao Brian Yu
, Kali M. Pruss
, Rita Almeida Oliveira
, Steven Kyle Higginbottom
, Norma F. Neff
, Michael Andrew Fischbach
, Karina Bivar Xavier
, Justin Laine Sonnenburg
, Kerwyn Casey Huang

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

Ng et al. systematically compare microbiota responses to antibiotics in mice. A fiber-deficient diet or single housing aggravated otherwise rapid recovery, whereas microbiota reprogramming through repeated treatment or transmission between hosts enhanced resilience. This work highlights the translational potential for modulating diet, sanitation, and microbiota composition during antibiotic treatment.

Original language	English
Pages (from-to)	650-665.e4
Journal	Cell Host and Microbe
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2019.10.011
State	Published - Nov 13 2019

Keywords

antibiotics
Bacteroides
co-housing
coprophagia
fecal microbiota transplants
gut microbiota
microbiota perturbations
reseeding
resilience
S24-7

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10.1016/j.chom.2019.10.011

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Ng, K. M., Aranda-Díaz, A., Tropini, C., Frankel, M. R., Van Treuren, W., O'Laughlin, C. T., Merrill, B. D., Yu, F. B., Pruss, K. M., Oliveira, R. A., Higginbottom, S. K., Neff, N. F., Fischbach, M. A., Xavier, K. B., Sonnenburg, J. L., & Huang, K. C. (2019). Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs. Cell Host and Microbe, 26(5), 650-665.e4. https://doi.org/10.1016/j.chom.2019.10.011

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title = "Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs",

abstract = "Ng et al. systematically compare microbiota responses to antibiotics in mice. A fiber-deficient diet or single housing aggravated otherwise rapid recovery, whereas microbiota reprogramming through repeated treatment or transmission between hosts enhanced resilience. This work highlights the translational potential for modulating diet, sanitation, and microbiota composition during antibiotic treatment.",

keywords = "antibiotics, Bacteroides, co-housing, coprophagia, fecal microbiota transplants, gut microbiota, microbiota perturbations, reseeding, resilience, S24-7",

author = "Ng, \{Katharine Michelle\} and Andr{\'e}s Aranda-D{\'i}az and Carolina Tropini and Frankel, \{Matthew Ryan\} and \{Van Treuren\}, William and O'Laughlin, \{Colleen T.\} and Merrill, \{Bryan Douglas\} and Yu, \{Feiqiao Brian\} and Pruss, \{Kali M.\} and Oliveira, \{Rita Almeida\} and Higginbottom, \{Steven Kyle\} and Neff, \{Norma F.\} and Fischbach, \{Michael Andrew\} and Xavier, \{Karina Bivar\} and Sonnenburg, \{Justin Laine\} and Huang, \{Kerwyn Casey\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

day = "13",

doi = "10.1016/j.chom.2019.10.011",

language = "English",

volume = "26",

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journal = "Cell Host and Microbe",

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Ng, KM, Aranda-Díaz, A, Tropini, C, Frankel, MR, Van Treuren, W, O'Laughlin, CT, Merrill, BD, Yu, FB, Pruss, KM, Oliveira, RA, Higginbottom, SK, Neff, NF, Fischbach, MA, Xavier, KB, Sonnenburg, JL & Huang, KC 2019, 'Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs', Cell Host and Microbe, vol. 26, no. 5, pp. 650-665.e4. https://doi.org/10.1016/j.chom.2019.10.011

TY - JOUR

T1 - Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

AU - Ng, Katharine Michelle

AU - Aranda-Díaz, Andrés

AU - Tropini, Carolina

AU - Frankel, Matthew Ryan

AU - Van Treuren, William

AU - O'Laughlin, Colleen T.

AU - Merrill, Bryan Douglas

AU - Yu, Feiqiao Brian

AU - Pruss, Kali M.

AU - Oliveira, Rita Almeida

AU - Higginbottom, Steven Kyle

AU - Neff, Norma F.

AU - Fischbach, Michael Andrew

AU - Xavier, Karina Bivar

AU - Sonnenburg, Justin Laine

AU - Huang, Kerwyn Casey

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Ng et al. systematically compare microbiota responses to antibiotics in mice. A fiber-deficient diet or single housing aggravated otherwise rapid recovery, whereas microbiota reprogramming through repeated treatment or transmission between hosts enhanced resilience. This work highlights the translational potential for modulating diet, sanitation, and microbiota composition during antibiotic treatment.

AB - Ng et al. systematically compare microbiota responses to antibiotics in mice. A fiber-deficient diet or single housing aggravated otherwise rapid recovery, whereas microbiota reprogramming through repeated treatment or transmission between hosts enhanced resilience. This work highlights the translational potential for modulating diet, sanitation, and microbiota composition during antibiotic treatment.

KW - antibiotics

KW - Bacteroides

KW - co-housing

KW - coprophagia

KW - fecal microbiota transplants

KW - gut microbiota

KW - microbiota perturbations

KW - reseeding

KW - resilience

KW - S24-7

UR - https://www.scopus.com/pages/publications/85074515913

U2 - 10.1016/j.chom.2019.10.011

DO - 10.1016/j.chom.2019.10.011

M3 - Article

C2 - 31726029

AN - SCOPUS:85074515913

SN - 1931-3128

VL - 26

SP - 650-665.e4

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 5

ER -

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

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