@article{e3f4c02c9af142e29411c3b6863ce512,
title = "Recommendations on RBC transfusion in critically ill children with acute brain injury from the pediatric critical care transfusion and anemia expertise initiative",
abstract = "Objectives: To present the recommendations and supporting literature for RBC transfusions in critically ill children with acute brain injury developed by the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Design: Consensus conference series of international, multidis-ciplinary experts in RBC transfusion management of critically ill children. Methods: The panel of 38 experts developed evidence-based, and when evidence was lacking, expert-based clinical recommendations as well as research priorities for RBC transfusions in critically ill children. The acute brain injury subgroup included three experts. Electronic searches were conducted using PubMed, EMBASE, and Cochrane Library databases jrom 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. Results: Transfusion and Anemia Expertise Initiative Consensus Conference experts developed and agreed upon two clinical and two research recommendations focused on RBC transfusion in the critically ill child with acute brain injury. Recommendations include consideration of RBC transfusion for a hemoglobin concentration between 7 and 10 g/dL in patients with acute brain injury and do not support the use of brain tissue PO2 monitoring to guide RBC transfusion decisions. Research is needed to better understand transfusion thresholds and brain tissue monitoring for pediatric patients with acute brain injury. Conclusions: The Transfusion and Anemia Expertise Initiative Consensus Conference developed pediatric-specific clinical and research recommendations regarding RBC transfusion in the critically ill child with acute brain injury. Although agreement among experts was very strong, the available pediatric evidence was extremely limited with major gaps in the literature.",
keywords = "Acute brain injury, Blood, Red blood cell, Stroke, Transfusion, Traumatic brain injury",
author = "Tasker, {Robert C.} and Turgeon, {Alexis F.} and Spinella, {Philip C.}",
note = "Funding Information: 1Department of Neurology, Harvard Medical School, Boston Children{\textquoteright}s Hospital, Boston, MA. 2Division of Critical Care Medicine, Department of Anesthesia (Pediatrics), Harvard Medical School, Boston Children{\textquoteright}s Hospital, Boston, MA. 3Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, and CHU de Qu{\'e}bec – Universit{\'e} Laval Research Center (Population Health and Optimal Health Practices Research Unit), Universit{\'e} Laval, Qu{\'e}bec City, QC, Canada. 4Division of Critical Care, Department of Pediatrics, Washington University in St Louis, St Louis, MO. Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI) members are listed in Appendix 1. The Transfusion and Anemia Expertise Initiative was supported, in part, by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Heart, Lung, and Blood Institute under award number 1 R13 HD088086-01, the Society for the Advancement of Blood Management (SABM)-Haemonetics Research Starter Grant, the CHU-Sainte-Justine Foundation, the Washington University Children{\textquoteright}s Discovery Institute (CDI-E1-2015–499), and the University of Massachusetts Medical School. Funding Information: Dr. Spinella received funding from New Health Sciences. The remaining Funding Information: The Transfusion and Anemia Expertise Initiative was supported, in part, by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Heart, Lung, and Blood Institute under award number 1 R13 HD088086-01, the Society for the Advancement of Blood Management (SABM)-Haemonetics Research Starter Grant, the CHU-Sainte-Justine Foundation, the Washington University Children's Discovery Institute (CDI-E1-2015-499), and the University of Massachusetts Medical School. Dr. Spinella received funding from New Health Sciences. The remaining authors have disclosed that they do not have any potential conflicts of interest. Publisher Copyright: Copyright {\textcopyright} 2018 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.",
year = "2018",
doi = "10.1097/PCC.0000000000001589",
language = "English",
volume = "19",
pages = "S133--S136",
journal = "Pediatric Critical Care Medicine",
issn = "1529-7535",
number = "9",
}