TY - JOUR
T1 - Recognition of infected cells by natural killer cells
AU - Carayannopoulos, Leonidas N.
AU - Yokoyama, Wayne M.
N1 - Funding Information:
We apologize to our colleagues whose work was not highlighted due to space constraints. LNC is supported by a Howard Hughes Medical Institute postdoctoral fellowship award. The Yokoyama laboratory is supported by the Howard Hughes Medical Institute the Barnes-Jewish Hospital Foundation, the National Institutes of Health, and the Midwest Regional Center for Excellence in Biodefense and Emerging Infectious Diseases Research.
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Under the influence of cytokines associated with innate immunity, natural killer (NK) cells rapidly become activated and migrate to sites of infection. Upon contact with infected parenchyma they proliferate, release cytokines and/ or kill cells harboring pathogens. Multiple stimulatory and inhibitory receptors can provide the integrated signals that trigger this contact-mediated NK-cell function. Recent work has begun to define the ligands for these receptors in the context of infection by certain well-studied viruses. These results, in addition to future work involving other pathogens, will provide an understanding of the molecules present on parasitized cells that mark them as targets of innate immunity.
AB - Under the influence of cytokines associated with innate immunity, natural killer (NK) cells rapidly become activated and migrate to sites of infection. Upon contact with infected parenchyma they proliferate, release cytokines and/ or kill cells harboring pathogens. Multiple stimulatory and inhibitory receptors can provide the integrated signals that trigger this contact-mediated NK-cell function. Recent work has begun to define the ligands for these receptors in the context of infection by certain well-studied viruses. These results, in addition to future work involving other pathogens, will provide an understanding of the molecules present on parasitized cells that mark them as targets of innate immunity.
UR - http://www.scopus.com/inward/record.url?scp=1042286467&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2003.11.003
DO - 10.1016/j.coi.2003.11.003
M3 - Review article
C2 - 14734107
AN - SCOPUS:1042286467
SN - 0952-7915
VL - 16
SP - 26
EP - 33
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -