Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609

N. P. Reed, M. A. Henderson, E. M. Oltz, T. M. Aune

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Recombination-activating gene 1 (Rag1) and Rag2 enzymes are required for T cell receptor assembly and thymocyte development. The mechanisms underlying the transcriptional activation and repression of Rag1 and Rag2 are incompletely understood. The zinc-finger protein, Zfp608, represses Rag1 and Rag2 expression when expressed in thymocytes blocking T-cell maturation. Here we show that the related zinc-finger protein, Zfp609, is necessary for Rag1 and Rag2 expression in developing thymocytes. Zfp608 represses Rag1 and Rag2 expression indirectly by repressing the expression of Zfp609. Thus, the balance of Zfp608 and Zfp609 plays a critical role in regulating Rag1 and Rag2 expression, which may manifest itself not only during development of immature thymocytes into mature T cells but also in generation of the T-cell arm of the adaptive immune system, which does not fully develop until after birth.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalGenes and Immunity
Volume14
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Rag
  • Zfp608
  • Zfp609
  • immune system
  • thymus

Fingerprint

Dive into the research topics of 'Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609'. Together they form a unique fingerprint.

Cite this