Receptors for the age of anxiety: Pharmacology of the benzodiazepines

John F. Tallman, Steven M. Paul, Phil Skolnick, Dorothy W. Gallager

Research output: Contribution to journalArticle

647 Scopus citations

Abstract

Investigation of the actions of the benzodiazepines has provided insights into the neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation: Behavioral, electrophysiological, pharmacological, and biochemical evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain. The benzodiazepine receptor interacts with a receptor for γ-aminobutyric acid, a major inhibitory neurotransmitter, and enhances its inhibitory effects. The benzodiazepine receptor may also interact with endogenous substances and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Both the purines and nicotinamide possess some benzodiazepine-like properties in vivo, although further work will be required to confirm their possible roles as endogenous benzodiazepines.

Original languageEnglish
Pages (from-to)274-281
Number of pages8
JournalScience
Volume207
Issue number4428
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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