TY - JOUR
T1 - Receptors for laminin on mammalian cells
AU - Mecham, R. P.
PY - 1991
Y1 - 1991
N2 - Early in development, cells produce an extracellular matrix that provides important cues that regulate gene expression, cell division, and morphogenesis. Interactions with the extracellular matrix are mediated by cell-surface receptors providing a transmembrane link between extracellular and intracellular compartments. Laminin, a large, multichain glycoprotein found in basement membranes, is involved in various biological activities, including promotion of cell adhesion, growth, migration, differentiation, neurite outgrowth, and tumor metastases. To date, several classes of binding proteins have been found to interact with laminin, including a high-affinity 67-kDa receptor, galactoside-binding lectins, galactosyltransferase, sulfatides, and integrins. This review will summarize our current understanding of some of these laminin-binding proteins, and where possible, integrate the biochemistry and cell biology of ligand and receptor expression.
AB - Early in development, cells produce an extracellular matrix that provides important cues that regulate gene expression, cell division, and morphogenesis. Interactions with the extracellular matrix are mediated by cell-surface receptors providing a transmembrane link between extracellular and intracellular compartments. Laminin, a large, multichain glycoprotein found in basement membranes, is involved in various biological activities, including promotion of cell adhesion, growth, migration, differentiation, neurite outgrowth, and tumor metastases. To date, several classes of binding proteins have been found to interact with laminin, including a high-affinity 67-kDa receptor, galactoside-binding lectins, galactosyltransferase, sulfatides, and integrins. This review will summarize our current understanding of some of these laminin-binding proteins, and where possible, integrate the biochemistry and cell biology of ligand and receptor expression.
KW - 67-kDa receptor
KW - Elastin
KW - Integrins
KW - Laminin
KW - Lectin
UR - http://www.scopus.com/inward/record.url?scp=0026093621&partnerID=8YFLogxK
U2 - 10.1096/fasebj.5.11.1651264
DO - 10.1096/fasebj.5.11.1651264
M3 - Review article
C2 - 1651264
AN - SCOPUS:0026093621
VL - 5
SP - 2538
EP - 2546
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 11
ER -