Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of wnt signaling in renal cancer

Neal R. Rasmussen, Tricia M. Wright, Samira A. Brooks, Kathryn E. Hacker, Zufan Debebe, Adam B. Sendor, Matthew P. Walker, Michael Ben Major, Jennifer Green, Geoffrey M. Wahl, W. Kimryn Rathmell

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Expression of Ror2 leads to increased tumorigenicity in RCC. Results: Ror2 expression stabilizes an increased pool of soluble β-catenin, which enhances the response to Wnt stimulation. Conclusion: Ror2 promotes basal and canonical Wnt3a ligand-enhanced β-catenin signaling in RCC. Significance: This work demonstrates a novel Ror2-dependent tiered state of canonical Wnt signaling, promoting basal signals and priming RCC cells for a heightened response to the ligand.

Original languageEnglish
Pages (from-to)26301-26310
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

Fingerprint Dive into the research topics of 'Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of wnt signaling in renal cancer'. Together they form a unique fingerprint.

Cite this