Receptor trafficking hypothesis revisited: Plasticity of AMPA receptors during established status epilepticus

Karthik Rajasekaran, Suchitra Joshi, Maxim Kozhemyakin, Marko S. Todorovic, Samuel Kowalski, Corinne Balint, Jaideep Kapur

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Status epilepticus (SE) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor (AMPAR)-mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR-mediated excitatory postsynaptic currents at Schaffer collateral -CA1 pyramidal neuron synapses during ESE. Surface expression of the GluA1 subunit increased, and this was a consequence of N-methyl-D-aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE. These studies suggest that AMPAR-mediated glutamatergic transmission is strengthened during ESE.

Original languageEnglish
Pages (from-to)14-16
Number of pages3
JournalEpilepsia
Volume54
Issue numberSUPPL. 6
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Keywords

  • AMPA receptor
  • CA1 pyramidal neurons
  • Glutamate
  • Plasticity
  • Receptor trafficking
  • Status epilepticus

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    Rajasekaran, K., Joshi, S., Kozhemyakin, M., Todorovic, M. S., Kowalski, S., Balint, C., & Kapur, J. (2013). Receptor trafficking hypothesis revisited: Plasticity of AMPA receptors during established status epilepticus. Epilepsia, 54(SUPPL. 6), 14-16. https://doi.org/10.1111/epi.12266