Abstract
Status epilepticus (SE) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor (AMPAR)-mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR-mediated excitatory postsynaptic currents at Schaffer collateral -CA1 pyramidal neuron synapses during ESE. Surface expression of the GluA1 subunit increased, and this was a consequence of N-methyl-D-aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE. These studies suggest that AMPAR-mediated glutamatergic transmission is strengthened during ESE.
Original language | English |
---|---|
Pages (from-to) | 14-16 |
Number of pages | 3 |
Journal | Epilepsia |
Volume | 54 |
Issue number | SUPPL. 6 |
DOIs | |
State | Published - 2013 |
Keywords
- AMPA receptor
- CA1 pyramidal neurons
- Glutamate
- Plasticity
- Receptor trafficking
- Status epilepticus