Receptor-mediated reversible translocation of the G protein βγ complex from the plasma membrane to the golgi complex

Muslum Akgoz, Vani Kalyanaraman, N. Gautam

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Heterotrimeric G proteins have been thought to function on the plasma membrane after activation by transmembrane receptors. Here we show that, after activation by receptors, the G protein βγ complex selectively translocates to the Golgi. Receptor inactivation results in Gβγ translocating back to the plasma membrane. Both translocation processes occur rapidly within seconds. The efficiency of translocation is influenced by the type of γ subunit present in the G protein. Distinctly different receptor types are capable of inducing the translocation. Receptor-mediated translocation of Gβγ can spatially segregate G protein signaling activity.

Original languageEnglish
Pages (from-to)51541-51544
Number of pages4
JournalJournal of Biological Chemistry
Volume279
Issue number49
DOIs
StatePublished - Dec 3 2004

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