TY - JOUR
T1 - Recent progress in West Nile virus diagnosis and vaccination
AU - De Filette, Marina
AU - Ulbert, Sebastian
AU - Diamond, Michael S.
AU - Sanders, Niek N.
PY - 2012
Y1 - 2012
N2 - West Nile virus (WNV) is a positive-stranded RNA virus belonging to the Flaviviridae family, a large family with 3 main genera (flavivirus, hepacivirus and pestivirus). Among these viruses, there are several globally relevant human pathogens including the mosquito-borne dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV). Since the mid-1990s, outbreaks of WN fever and encephalitis have occurred throughout the world and WNV is now endemic in Africa, Asia, Australia, the Middle East, Europe and the Unites States. This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.
AB - West Nile virus (WNV) is a positive-stranded RNA virus belonging to the Flaviviridae family, a large family with 3 main genera (flavivirus, hepacivirus and pestivirus). Among these viruses, there are several globally relevant human pathogens including the mosquito-borne dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV). Since the mid-1990s, outbreaks of WN fever and encephalitis have occurred throughout the world and WNV is now endemic in Africa, Asia, Australia, the Middle East, Europe and the Unites States. This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.
UR - http://www.scopus.com/inward/record.url?scp=84864491282&partnerID=8YFLogxK
U2 - 10.1186/1297-9716-43-16
DO - 10.1186/1297-9716-43-16
M3 - Review article
C2 - 22380523
AN - SCOPUS:84864491282
SN - 0928-4249
VL - 43
JO - Veterinary Research
JF - Veterinary Research
IS - 1
M1 - 16
ER -