Recent progress in West Nile virus diagnosis and vaccination

Marina De Filette, Sebastian Ulbert, Michael S. Diamond, Niek N. Sanders

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations

Abstract

West Nile virus (WNV) is a positive-stranded RNA virus belonging to the Flaviviridae family, a large family with 3 main genera (flavivirus, hepacivirus and pestivirus). Among these viruses, there are several globally relevant human pathogens including the mosquito-borne dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV). Since the mid-1990s, outbreaks of WN fever and encephalitis have occurred throughout the world and WNV is now endemic in Africa, Asia, Australia, the Middle East, Europe and the Unites States. This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.

Original languageEnglish
Article number16
JournalVeterinary Research
Volume43
Issue number1
DOIs
StatePublished - 2012

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