Recent progress in microfluidic devices for nucleic acid and antibody assays

Ponnambalam Ravi Selvaganapathy, Edwin T. Carlen, Carlos H. Mastrangelo

    Research output: Contribution to journalReview articlepeer-review

    39 Scopus citations

    Abstract

    Microfluidic devices are increasingly important in biomedical assays. In this paper, we review recent progress on these devices for chemical amplification, hybridization, separation, and detection of nucleic acids. Recent developments in microfluidic technologies for detection of protein binding events in immunoassay applications are also reviewed.

    Original languageEnglish
    Pages (from-to)954-975
    Number of pages22
    JournalProceedings of the IEEE
    Volume91
    Issue number6
    DOIs
    StatePublished - 2003

    Keywords

    • DNA
    • Immunoassays
    • Microelectromechnical systems (MEMS)
    • Microfluidic assays

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