TY - JOUR
T1 - Recent insights into the role of tumor necrosis factor in the failing heart
AU - Mann, Douglas L.
N1 - Funding Information:
The author would like to thank Mary Helen Soliz for secretarial assistance, as well as Dr. Andrew I. Schafer for his past and present guidance and support. The research reviewed herein was supported, in part, by research funds from the Department of Veterans Affairs and the N.I.H. (P50 HL-O6H and RO1 HL58081-01, RO1 HL61543-01, HL-42250-10=10).
PY - 2001
Y1 - 2001
N2 - Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
AB - Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
KW - Cytokine
KW - Heart failure
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=0035064105&partnerID=8YFLogxK
U2 - 10.1023/A:1011449708842
DO - 10.1023/A:1011449708842
M3 - Review article
C2 - 11309526
AN - SCOPUS:0035064105
SN - 1382-4147
VL - 6
SP - 71
EP - 80
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 2
ER -