TY - JOUR
T1 - Recent Insights into Kidney Injury and Repair from Transcriptomic Analyses
AU - Kirita, Yuhei
AU - Chang-Panesso, Monica
AU - Humphreys, Benjamin D.
N1 - Funding Information:
Work in the Humphreys Lab is supported by NIH/NIDDK grants DK103740 and DK107374 and by the NIDDK Diabetic Complications Consortium (DiaComp, www.diacomp.org) grants DK076169 and DK115255 (all to B.D.H).
Funding Information:
Contribution from the AKI and CRRT 2019 Symposium at the 24th International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, February 26 – March 1, 2019. This symposium was supported in part by the NIDDK funded University of Alabama at Birmingham-University of California San Diego O’Brien Center for Acute Kidney Injury Research (P30DK079337).
Publisher Copyright:
© 2019 S. Karger AG, Basel. All rights reserved.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Injured tubular epithelium exhibits cellular plasticity in that it can dedifferentiate, reenter the cell cycle, and subsequently either redifferentiate or adopt a chronically injured phenotype. Although some nephrogenic genes are reexpressed during injury and repair, developmental pathways are only partially recapitulated and the process is more accurately viewed as an entirely new program intrinsic to the regenerative response to injury. Recent advances in our understanding of the molecular circuitry underpinning epithelial plasticity have come from bulk, cell-specific, and single-cell transcriptomic analyses. These results have begun to define the signaling pathways and gene regulatory networks governing the epithelial injury response. In this review, we highlight recent transcriptomic analyses in kidney injury, repair and fibrosis, and outline the ways that these studies are improving our understanding of kidney regeneration.
AB - Injured tubular epithelium exhibits cellular plasticity in that it can dedifferentiate, reenter the cell cycle, and subsequently either redifferentiate or adopt a chronically injured phenotype. Although some nephrogenic genes are reexpressed during injury and repair, developmental pathways are only partially recapitulated and the process is more accurately viewed as an entirely new program intrinsic to the regenerative response to injury. Recent advances in our understanding of the molecular circuitry underpinning epithelial plasticity have come from bulk, cell-specific, and single-cell transcriptomic analyses. These results have begun to define the signaling pathways and gene regulatory networks governing the epithelial injury response. In this review, we highlight recent transcriptomic analyses in kidney injury, repair and fibrosis, and outline the ways that these studies are improving our understanding of kidney regeneration.
KW - Acute Kidney Injury
KW - RNA-sequencing
KW - Transcriptomics
UR - http://www.scopus.com/inward/record.url?scp=85066627743&partnerID=8YFLogxK
U2 - 10.1159/000500638
DO - 10.1159/000500638
M3 - Review article
C2 - 31112966
AN - SCOPUS:85066627743
VL - 143
SP - 162
EP - 165
JO - Nephron
JF - Nephron
SN - 1660-8151
IS - 3
ER -