Recent evolution of the human skin barrier

Erin A. Brettmann, Cristina de Guzman Strong

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The skin is the first line of defense against the environment, with the epidermis as the outermost tissue providing much of the barrier function. Given its direct exposure to and encounters with the environment, the epidermis must evolve to provide an optimal barrier for the survival of an organism. Recent advances in genomics have identified a number of genes for the human skin barrier that have undergone evolutionary changes since humans diverged from chimpanzees. Here, we highlight a selection of key and innovative genetic findings for skin barrier evolution in our divergence from our primate ancestors and among modern human populations.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalExperimental Dermatology
Volume27
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • epidermis
  • genetic selection
  • genomics
  • hominidae
  • skin

Fingerprint

Dive into the research topics of 'Recent evolution of the human skin barrier'. Together they form a unique fingerprint.

Cite this