Recent characterizations of MscS and its homologs provide insight into the basis of ion selectivity in mechanosensitive channels

Grigory Maksaev, Elizabeth S. Haswell

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The bacterial mechanosensitive channel MscS provides an excellent model system for the study of mechanosensitivity and for investigations into the cellular response to hypoosmotic shock. Numerous studies have elucidated the structure, function and gating mechanism of Escherichia coli MscS, providing a wealth of information for the comparative analysis of MscS family members in bacteria, archaea, fungi and plants. We recently reported the electrophysiological characterization of MscS-Like (MSL)10, a MscS homolog from the model flowering plant Arabidopsis thaliana. Here, we summarize our results and briefly compare MSL10 to previously described members of the MscS family. Finally, we comment on how this and other recently published studies illuminate the possible mechanisms by which ion selectivity is accomplished in this fascinating family of channels.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalChannels
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2013

Keywords

  • Arabidopsis
  • Ion channel
  • Mechanosensitive
  • MscS
  • MscS-Like
  • Xenopus oocyte

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