TY - JOUR
T1 - Recent cancer incidence trends in an observational clinical cohort of HIV-infected patients in the US, 2000 to 2011
AU - Yanik, Elizabeth L.
AU - Tamburro, Kristen
AU - Eron, Joseph J.
AU - Damania, Blossom
AU - Napravnik, Sonia
AU - Dittmer, Dirk P.
N1 - Funding Information:
This work was supported by a NCI AIDS malignancy supplement grant to the UNC Lineberger Cancer Center (CA016086) and the UNC Center for AIDS research (AI050410), the University Cancer Research Fund (UCRF), and RO1 DE018304 to DPD. EY is supported by the University of North Carolina at Chapel Hill Training in Sexually Transmitted Diseases and HIV NIH Grant (5 T32 AI007001-35). KT is supported by T32 GM07092-34 and by a grant to the University of North Carolina at Chapel Hill from Howard Hughes Medical Institute (HHMI) through the Med into Grad Initiative.
Funding Information:
This work was supported by a supplement grant to the UNC Lineberger Cancer Center (CA016086) and the UNC Center for AIDS research (AI050410) and RO1 DE018304 to DPD. EY is supported by the University of North Carolina at Chapel Hill Training in Sexually Transmitted Diseases and HIV NIH Grant (5 T32 AI007001-35). KT is supported by T32 GM07092-34 and by a grant to the University of North Carolina at Chapel Hill from Howard Hughes Medical Institute (HHMI) through the Med into Grad Initiative.
PY - 2013
Y1 - 2013
N2 - Background: In HIV-infected populations in developed countries, the most recent published cancer incidence trend analyses are only updated through 2008. We assessed changes in the distribution of cancer types and incidence trends among HIV-infected patients in North Carolina up until 2011. Methods. We linked the University of North Carolina Center for AIDS Research HIV Clinical Cohort, an observational clinical cohort of 3141 HIV-infected patients, with the North Carolina Cancer registry. Cancer incidence rates were estimated across calendar years from 2000 to 2011. The distribution of cancer types was described. Incidence trends were assessed with linear regression. Results: Across 15,022 person-years of follow-up, 202 cancers were identified (incidence rate per 100,000 person-years [IR]: 1345; 95% confidence interval [CI]: 1166, 1544). The majority of cancers were virus-related (61%), including Kaposi sarcoma (N = 32) (IR: 213; 95%CI: 146, 301), non-Hodgkin lymphoma (N = 34) (IR: 226; 95%CI: 157, 316), and anal cancer (N = 16) (IR: 107; 95%CI: 61, 173). Non-Hodgkin lymphoma was observed to decrease from 2000 to 2011 (decline of 15 cases per 100,000 person-years per calendar year, 95%CI: -27, -3). No other changes in incidence or changes in incidence trends were observed for other cancers (all P > 0.20). Conclusions: We observed a substantial burden of a variety of cancers in this population in the last decade. Kaposi sarcoma and non-Hodgkin lymphoma were consistently two of the greatest contributors to cancer burden across calendar time. Cancer rates appeared stable across calendar years, except for non-Hodgkin lymphoma, which appeared to decrease throughout the study period.
AB - Background: In HIV-infected populations in developed countries, the most recent published cancer incidence trend analyses are only updated through 2008. We assessed changes in the distribution of cancer types and incidence trends among HIV-infected patients in North Carolina up until 2011. Methods. We linked the University of North Carolina Center for AIDS Research HIV Clinical Cohort, an observational clinical cohort of 3141 HIV-infected patients, with the North Carolina Cancer registry. Cancer incidence rates were estimated across calendar years from 2000 to 2011. The distribution of cancer types was described. Incidence trends were assessed with linear regression. Results: Across 15,022 person-years of follow-up, 202 cancers were identified (incidence rate per 100,000 person-years [IR]: 1345; 95% confidence interval [CI]: 1166, 1544). The majority of cancers were virus-related (61%), including Kaposi sarcoma (N = 32) (IR: 213; 95%CI: 146, 301), non-Hodgkin lymphoma (N = 34) (IR: 226; 95%CI: 157, 316), and anal cancer (N = 16) (IR: 107; 95%CI: 61, 173). Non-Hodgkin lymphoma was observed to decrease from 2000 to 2011 (decline of 15 cases per 100,000 person-years per calendar year, 95%CI: -27, -3). No other changes in incidence or changes in incidence trends were observed for other cancers (all P > 0.20). Conclusions: We observed a substantial burden of a variety of cancers in this population in the last decade. Kaposi sarcoma and non-Hodgkin lymphoma were consistently two of the greatest contributors to cancer burden across calendar time. Cancer rates appeared stable across calendar years, except for non-Hodgkin lymphoma, which appeared to decrease throughout the study period.
KW - AIDS
KW - AIDS-associated malignancies
KW - Cancer
KW - HIV
KW - Kaposi sarcoma
UR - http://www.scopus.com/inward/record.url?scp=84878006850&partnerID=8YFLogxK
U2 - 10.1186/1750-9378-8-18
DO - 10.1186/1750-9378-8-18
M3 - Article
C2 - 23705808
AN - SCOPUS:84878006850
SN - 1750-9378
VL - 8
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
IS - 1
M1 - 18
ER -