Recent applications of circular dichroism to structural problems, especially oligosaccharide structures

Koji Nakanishi; Masanori Kuroyanagi; Hirofumi Nambu; Eugene M. Oltz; Reiji Takeda; Gregory L. Verdine; Arie Zask

doi:10.1351/pac198456081031

Recent applications of circular dichroism to structural problems, especially oligosaccharide structures

Koji Nakanishi, Masanori Kuroyanagi, Hirofumi Nambu, Eugene M. Oltz, Reiji Takeda, Gregory L. Verdine, Arie Zask

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

First, a brief review of the exciton chirality method is given, with emphasis on practical aspects. This is followed by a case (mitomycin C) in which the interpretation of CD data is purposely carried out in a wavelength region where undesirable interchromophoric interaction is negligible. A new chromophore for coupled CD studies and the additivity relation in coupled CD is mentioned. Generalized schemes for carrying out micro- (**) scale structural studies of oligosaccharides, namely identification of sugars and their glycosidic linkages, are described. The simple three-step sequence currently under study is based on the remarkable additivity relationship found in the coupled CD of pyranose p-methoxycarbonyl benzyl ethers.

Original language	English
Pages (from-to)	1031-1048
Number of pages	18
Journal	Pure and Applied Chemistry
Volume	56
Issue number	8
DOIs	https://doi.org/10.1351/pac198456081031
State	Published - Jan 1 1984

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title = "Recent applications of circular dichroism to structural problems, especially oligosaccharide structures",

abstract = "First, a brief review of the exciton chirality method is given, with emphasis on practical aspects. This is followed by a case (mitomycin C) in which the interpretation of CD data is purposely carried out in a wavelength region where undesirable interchromophoric interaction is negligible. A new chromophore for coupled CD studies and the additivity relation in coupled CD is mentioned. Generalized schemes for carrying out micro- (**) scale structural studies of oligosaccharides, namely identification of sugars and their glycosidic linkages, are described. The simple three-step sequence currently under study is based on the remarkable additivity relationship found in the coupled CD of pyranose p-methoxycarbonyl benzyl ethers.",

author = "Koji Nakanishi and Masanori Kuroyanagi and Hirofumi Nambu and Oltz, {Eugene M.} and Reiji Takeda and Verdine, {Gregory L.} and Arie Zask",

note = "Funding Information: Acknowledgements - We are indebted to Dr. H.—W. Liu and other colleagues, Drs. M. DiNovi, J. Furukawa, 3. Golik, M. Nakatani, R.J. Stonard and D.A. Trainor, who were involved in the early stages of this study (see references cited). These studies are supported by a grant from the National Inst itues of Health (CA 11572)",

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doi = "10.1351/pac198456081031",

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T1 - Recent applications of circular dichroism to structural problems, especially oligosaccharide structures

AU - Nakanishi, Koji

AU - Kuroyanagi, Masanori

AU - Nambu, Hirofumi

AU - Oltz, Eugene M.

AU - Takeda, Reiji

AU - Verdine, Gregory L.

AU - Zask, Arie

N1 - Funding Information: Acknowledgements - We are indebted to Dr. H.—W. Liu and other colleagues, Drs. M. DiNovi, J. Furukawa, 3. Golik, M. Nakatani, R.J. Stonard and D.A. Trainor, who were involved in the early stages of this study (see references cited). These studies are supported by a grant from the National Inst itues of Health (CA 11572)

PY - 1984/1/1

Y1 - 1984/1/1

N2 - First, a brief review of the exciton chirality method is given, with emphasis on practical aspects. This is followed by a case (mitomycin C) in which the interpretation of CD data is purposely carried out in a wavelength region where undesirable interchromophoric interaction is negligible. A new chromophore for coupled CD studies and the additivity relation in coupled CD is mentioned. Generalized schemes for carrying out micro- (**) scale structural studies of oligosaccharides, namely identification of sugars and their glycosidic linkages, are described. The simple three-step sequence currently under study is based on the remarkable additivity relationship found in the coupled CD of pyranose p-methoxycarbonyl benzyl ethers.

AB - First, a brief review of the exciton chirality method is given, with emphasis on practical aspects. This is followed by a case (mitomycin C) in which the interpretation of CD data is purposely carried out in a wavelength region where undesirable interchromophoric interaction is negligible. A new chromophore for coupled CD studies and the additivity relation in coupled CD is mentioned. Generalized schemes for carrying out micro- (**) scale structural studies of oligosaccharides, namely identification of sugars and their glycosidic linkages, are described. The simple three-step sequence currently under study is based on the remarkable additivity relationship found in the coupled CD of pyranose p-methoxycarbonyl benzyl ethers.

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EP - 1048

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

SN - 0033-4545

IS - 8

ER -

Recent applications of circular dichroism to structural problems, especially oligosaccharide structures

Abstract

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