TY - JOUR
T1 - Recent advances toward the clinical application of PTH (1-34) in fracture healing
AU - Cipriano, Cara A.
AU - Issack, Paul S.
AU - Shindle, Lisa
AU - Werner, Clément M.L.
AU - Helfet, David L.
AU - Lane, Joseph M.
N1 - Funding Information:
One or more of the authors (JML) has received funding from (Eli Lilly)
PY - 2009/9
Y1 - 2009/9
N2 - PTH 1-34, an active form of parathyroid hormone, has been shown to enhance osteoblastic bone formation when administered as a daily subcutaneous injection. The effect of the intermittent administration of PTH (1-34) is an uncoupling of bone turnover with an increase in bone mass and density and decrease in risk of vertebral and nonvertebral fractures. While PTH (1-34) has been used clinically to increase bone mass and reduce fracture risk in postmenopausal women with osteoporosis, there is increasing evidence that PTH (1-34) may promote fracture healing. Animal studies have demonstrated accelerated callus formation with enhanced remodeling and biomechanical properties of the healing fracture. Given these effects, PTH (1-34) will likely be used clinically to enhance fracture union in poor healing situations such as osteoporosis and recalcitrant nonunions.
AB - PTH 1-34, an active form of parathyroid hormone, has been shown to enhance osteoblastic bone formation when administered as a daily subcutaneous injection. The effect of the intermittent administration of PTH (1-34) is an uncoupling of bone turnover with an increase in bone mass and density and decrease in risk of vertebral and nonvertebral fractures. While PTH (1-34) has been used clinically to increase bone mass and reduce fracture risk in postmenopausal women with osteoporosis, there is increasing evidence that PTH (1-34) may promote fracture healing. Animal studies have demonstrated accelerated callus formation with enhanced remodeling and biomechanical properties of the healing fracture. Given these effects, PTH (1-34) will likely be used clinically to enhance fracture union in poor healing situations such as osteoporosis and recalcitrant nonunions.
UR - http://www.scopus.com/inward/record.url?scp=70350660877&partnerID=8YFLogxK
U2 - 10.1007/s11420-009-9109-8
DO - 10.1007/s11420-009-9109-8
M3 - Article
C2 - 19290582
AN - SCOPUS:70350660877
VL - 5
SP - 149
EP - 153
JO - HSS Journal
JF - HSS Journal
SN - 1556-3316
IS - 2
ER -