Introduction: Spatial neglect remains an underdiagnosed and undertreated consequence of stroke that imposes significant disability. A growing appreciation of brain networks involved in spatial cognition is helping us to develop a mechanistic understanding of different therapies under development. Areas covered: This review focuses on neuromodulation of brain networks for the treatment of spatial neglect after stroke, using evidence-based approaches including 1) Cognitive strategies that are more likely to impact frontal lobe executive function networks; 2) Visuomotor adaptation, which may depend on the integrity of parietal and parieto- and subcortical-frontal connections and the presence of a particular subtype of neglect labeled Aiming neglect; 3) Non-invasive brain stimulation that may modulate relative levels of activity of the two hemispheres and depend on corpus callosum connectivity; and 4) Pharmacological modulation that may exert its effect primarily via right-lateralized networks more closely involved in arousal. Expert opinion: Despite promising results from individual studies, significant methodological heterogeneity between trials weakened conclusions drawn from meta-analyses. Improved classification of spatial neglect subtypes will benefit research and clinical care. Understanding the brain network mechanisms of different treatments and different types of spatial neglect will make possible a precision medicine treatment approach.

Original languageEnglish
Pages (from-to)587-601
Number of pages15
JournalExpert Review of Neurotherapeutics
Issue number7
StatePublished - 2023


  • Aiming neglect
  • brain networks
  • neuromodulation
  • precision medicine
  • prism adaptation
  • rehabilitation
  • spatial neglect
  • stroke
  • transcranial magnetic stimulation
  • visual scanning


Dive into the research topics of 'Recent advances in treatment of spatial neglect: networks and neuropsychology'. Together they form a unique fingerprint.

Cite this