TY - JOUR
T1 - Recent advances in the use of MRI to assess early human cortical development
AU - Neil, Jeffrey J.
AU - Smyser, Christopher D.
N1 - Funding Information:
The perceptive reader may have noticed that no publications have been cited in this manuscript on which Dr. Joe Ackerman (senior) is a co-author. This is due, in part, to the clinical nature of the subject matter, but it is also because Joe has always been careful to not cast too long a shadow over his students, often putting their careers above his own in discussions of authorship. Despite not appearing in the citations, he was instrumental in training Dr. Neil and made valuable contributions to Dr. Smyser’s education. He is an intelligent, patient and kind teacher with a unique sense of humor, and also a loyal friend. This work was supported by the National Institutes of Health (grant numbers R01 MH113570 , K02 NS089852 , and UL1 TR000448 ), the Cerebral Palsy International Research Foundation , the Dana Foundation and the Child Neurology Foundation .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/8
Y1 - 2018/8
N2 - Over the past decade, a number of advanced magnetic resonance-based methods have been brought to bear on questions related to early development of the human cerebral cortex. Herein, we describe studies employing analysis of cortical surface folding (cortical cartography), cortical microstructure (diffusion anisotropy), and cortically-based functional networks (resting state-functional connectivity MRI). The fundamentals of each MR method are described, followed by a discussion of application of the method to developing cortex and potential clinical uses. We use premature birth as an exemplar of how these modalities can be used to investigate the effects of medical and environmental variables on early cortical development.
AB - Over the past decade, a number of advanced magnetic resonance-based methods have been brought to bear on questions related to early development of the human cerebral cortex. Herein, we describe studies employing analysis of cortical surface folding (cortical cartography), cortical microstructure (diffusion anisotropy), and cortically-based functional networks (resting state-functional connectivity MRI). The fundamentals of each MR method are described, followed by a discussion of application of the method to developing cortex and potential clinical uses. We use premature birth as an exemplar of how these modalities can be used to investigate the effects of medical and environmental variables on early cortical development.
KW - Brain development
KW - Cortical cartography
KW - Diffusion imaging
KW - Functional connectivity MRI
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=85048214965&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2018.05.013
DO - 10.1016/j.jmr.2018.05.013
M3 - Article
C2 - 29894905
AN - SCOPUS:85048214965
VL - 293
SP - 56
EP - 69
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
SN - 1090-7807
ER -