TY - JOUR
T1 - Recent advances in the use of MRI to assess early human cortical development
AU - Neil, Jeffrey J.
AU - Smyser, Christopher D.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/8
Y1 - 2018/8
N2 - Over the past decade, a number of advanced magnetic resonance-based methods have been brought to bear on questions related to early development of the human cerebral cortex. Herein, we describe studies employing analysis of cortical surface folding (cortical cartography), cortical microstructure (diffusion anisotropy), and cortically-based functional networks (resting state-functional connectivity MRI). The fundamentals of each MR method are described, followed by a discussion of application of the method to developing cortex and potential clinical uses. We use premature birth as an exemplar of how these modalities can be used to investigate the effects of medical and environmental variables on early cortical development.
AB - Over the past decade, a number of advanced magnetic resonance-based methods have been brought to bear on questions related to early development of the human cerebral cortex. Herein, we describe studies employing analysis of cortical surface folding (cortical cartography), cortical microstructure (diffusion anisotropy), and cortically-based functional networks (resting state-functional connectivity MRI). The fundamentals of each MR method are described, followed by a discussion of application of the method to developing cortex and potential clinical uses. We use premature birth as an exemplar of how these modalities can be used to investigate the effects of medical and environmental variables on early cortical development.
KW - Brain development
KW - Cortical cartography
KW - Diffusion imaging
KW - Functional connectivity MRI
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=85048214965&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2018.05.013
DO - 10.1016/j.jmr.2018.05.013
M3 - Article
C2 - 29894905
AN - SCOPUS:85048214965
SN - 1090-7807
VL - 293
SP - 56
EP - 69
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
ER -