Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The interactions between pathogenic bacteria and their hosts are dynamic and multifaceted. The presence of bacterial pathogens at mucosal surfaces triggers a. vigorous inflammatory response that is essential for controlling the replication and spread of the intruder. However, inflammation also damages host tissue, and thus its induction must be tightly regulated. The molecular mechanisms underlying the stimulation of an inflammatory response by pathogenic bacteria have been elusive. The urinary tract infection (UTI) model system has been a powerful tool for understanding the interactions between cells of the innate host defense system, as well as the bacterial factors and host receptors involved in eliciting host cell activation. This article will discuss several recent findings that enhance our understanding of inflammatory effector mechanisms and pathogen recognition in the context of a mucosal surface.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalInternational Reviews of Immunology
Volume21
Issue number4-5
DOIs
StatePublished - Jul 2002

Keywords

  • E.coli
  • LPS
  • Toll-like receptors
  • Urinary tract infections

Fingerprint

Dive into the research topics of 'Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract'. Together they form a unique fingerprint.

Cite this