Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

Anne H. Schmieder, Shelton D. Caruthers, Jochen Keupp, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, 19F/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of 19F into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.

Original languageEnglish
Pages (from-to)475-489
Number of pages15
JournalEngineering
Volume1
Issue number4
DOIs
StatePublished - Dec 1 2015

Keywords

  • angiogenesis
  • cell labeling
  • dual-tuned coil
  • fluorine
  • magnetic resonance imaging (MRI)
  • perfluorocarbon

Fingerprint Dive into the research topics of 'Recent Advances in <sup>19</sup>Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions'. Together they form a unique fingerprint.

  • Cite this