Recent advances in polymeric vitreous substitutes

Katelyn E. Swindle, Nathan Ravi

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The vitreous humor occupies two thirds of the volume of the eye and is the major component behind the lens. The human vitreous is a gelatinous substance predominantly composed of water (98–99%). Its functions include holding the retina in place and circulating metabolites throughout the eye. The vitreous liquifies with age, facilitating posterior vitreous detachment, which can lead to retinal tears, intravitreal hemorrhage or retinal detachment. Vitreous substitutes are needed to tamponade the retina or during vitrectomies for treatment of retinal detachments. Gases, perfluorocarbon liquids and silicone or fluorosilicone oils are currently used as vitreous substitutes; however, none of these substitutes can be used long term due to the short retention time of the gaseous substitutes, cell toxicity or other complications, such as glaucoma or cataracts. Vitreous substitutes, both experimental and clinical, will be reviewed, along with promising experimental artificial vitreous; polymeric hydrogels.

Original languageEnglish
Pages (from-to)255-265
Number of pages11
JournalExpert Review of Ophthalmology
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2007

Keywords

  • hydrogel
  • in situ
  • polymer
  • vitrectomy
  • vitreous
  • vitreous substitute

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