Recent advances in chronic lymphocytic leukemia

N. Vyas, A. Hassan

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Chronic lymphocytic leukemia (CLL) was largely considered to be a disease of slow progression, standard treatment with Chlorambucil and having almost similar prognosis. With the introduction of molecular methods for understanding the disease pathophysiology in CLL there has been a remarkable change in the approach towards the disease. The variation in B-cell receptor response and immunoglobulin heavy chain variable region (IGHV) mutation, genetic aberration and defect in apoptosis and proliferation has had an impact on therapy initiation and prognosis. Early diagnosis of molecular variant is therefore necessary in CLL.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalIndian Journal of Cancer
Volume49
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Ataxia Telangiectasia Mutation
  • Zeta associated protein
  • immunoglobulin heavy chain variable region
  • somatic hyper mutation

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