Reassessment of HLA association with celiac disease in special reference to the DP association

Marco Colonna, Wilma Mantovani, Gino Roberto Corazza, Piero Barboni, Giovanni Gasbarrini, Giovanni Battista Ferrara, Roberto Tosi, Nobuyuki Tanigaki

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28 Scopus citations

Abstract

Patients with the late-onset form of celiac disease have been studied for HLA association by conventional serology (DR and DQ typing) and by oligonucleotide probing with gene amplification (DP typing). Patients and controls were sampled in the Bologna area of northern Italy. Almost all patients were positive for DQw2 (94%), being DR3 positive (72%) and/or DR7 positive (65%). The proportion of DR3/7 heterozygotes in the patients was significantly increased over that expected from the Hardy-Weinberg equilibrium. No positive association with DR5 and no significant increase of DR5/7 heterozygotes were observed. Among the DP alleles reported to exhibit an association with celiac disease in other populations, only DPB3 showed a moderate increase of a borderline significance, not attributable to a linkage disequilibrium with DQw2.

Original languageEnglish
Pages (from-to)263-274
Number of pages12
JournalHuman Immunology
Volume29
Issue number4
DOIs
StatePublished - Dec 1990

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