TY - JOUR
T1 - Reassessment of HLA association with celiac disease in special reference to the DP association
AU - Colonna, Marco
AU - Mantovani, Wilma
AU - Corazza, Gino Roberto
AU - Barboni, Piero
AU - Gasbarrini, Giovanni
AU - Ferrara, Giovanni Battista
AU - Tosi, Roberto
AU - Tanigaki, Nobuyuki
N1 - Funding Information:
The technical assistance of P. Overturf, L. Rendina, A.J. Trott, and R. Maturski is deeply appreciated. This work was supported in part by the USPH Grant no. AI02025 I, Progetto Finalizzato Oncologia N.87.01529.44, and Progetto Finalizzato Biotechnologie & Biostru-mentazione, CNR, N.89.00245.70.
PY - 1990/12
Y1 - 1990/12
N2 - Patients with the late-onset form of celiac disease have been studied for HLA association by conventional serology (DR and DQ typing) and by oligonucleotide probing with gene amplification (DP typing). Patients and controls were sampled in the Bologna area of northern Italy. Almost all patients were positive for DQw2 (94%), being DR3 positive (72%) and/or DR7 positive (65%). The proportion of DR3/7 heterozygotes in the patients was significantly increased over that expected from the Hardy-Weinberg equilibrium. No positive association with DR5 and no significant increase of DR5/7 heterozygotes were observed. Among the DP alleles reported to exhibit an association with celiac disease in other populations, only DPB3 showed a moderate increase of a borderline significance, not attributable to a linkage disequilibrium with DQw2.
AB - Patients with the late-onset form of celiac disease have been studied for HLA association by conventional serology (DR and DQ typing) and by oligonucleotide probing with gene amplification (DP typing). Patients and controls were sampled in the Bologna area of northern Italy. Almost all patients were positive for DQw2 (94%), being DR3 positive (72%) and/or DR7 positive (65%). The proportion of DR3/7 heterozygotes in the patients was significantly increased over that expected from the Hardy-Weinberg equilibrium. No positive association with DR5 and no significant increase of DR5/7 heterozygotes were observed. Among the DP alleles reported to exhibit an association with celiac disease in other populations, only DPB3 showed a moderate increase of a borderline significance, not attributable to a linkage disequilibrium with DQw2.
UR - http://www.scopus.com/inward/record.url?scp=0025674585&partnerID=8YFLogxK
U2 - 10.1016/0198-8859(90)90040-V
DO - 10.1016/0198-8859(90)90040-V
M3 - Article
C2 - 2286538
AN - SCOPUS:0025674585
SN - 0198-8859
VL - 29
SP - 263
EP - 274
JO - Human Immunology
JF - Human Immunology
IS - 4
ER -