Real-time imaging of lymphocytes in vivo

Michael D. Cahalan; Ian Parker; Sindy H. Wei; Mark J. Miller

doi:10.1016/S0952-7915(03)00079-7

Real-time imaging of lymphocytes in vivo

Michael D. Cahalan, Ian Parker, Sindy H. Wei, Mark J. Miller

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.

Original language	English
Pages (from-to)	372-377
Number of pages	6
Journal	Current Opinion in Immunology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/S0952-7915(03)00079-7
State	Published - Jun 2003

Access to Document

10.1016/S0952-7915(03)00079-7

Cite this

@article{17f9a001901f4457a21ee06d1377b167,

title = "Real-time imaging of lymphocytes in vivo",

abstract = "New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.",

author = "Cahalan, {Michael D.} and Ian Parker and Wei, {Sindy H.} and Miller, {Mark J.}",

year = "2003",

month = jun,

doi = "10.1016/S0952-7915(03)00079-7",

language = "English",

volume = "15",

pages = "372--377",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

number = "4",

}

TY - JOUR

T1 - Real-time imaging of lymphocytes in vivo

AU - Cahalan, Michael D.

AU - Parker, Ian

AU - Wei, Sindy H.

AU - Miller, Mark J.

PY - 2003/6

Y1 - 2003/6

N2 - New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.

AB - New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.

UR - http://www.scopus.com/inward/record.url?scp=0042405136&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(03)00079-7

DO - 10.1016/S0952-7915(03)00079-7

M3 - Review article

C2 - 12900266

AN - SCOPUS:0042405136

SN - 0952-7915

VL - 15

SP - 372

EP - 377

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 4

ER -

Real-time imaging of lymphocytes in vivo

Abstract

Access to Document

Other files and links

Fingerprint

Cite this