Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture

M. S. Hughes; J. N. Marsh; J. M. Arbeit; R. W. Fuhrhop; K. D. Wallace; T. Thomas; J. Smith; K. Agyem; G. M. Lanza; S. A. Wickline; J. E. McCarthy; M. V. Wickerhauser

doi:10.1109/ULTSYM.2009.5441843

Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture

M. S. Hughes, J. N. Marsh, J. M. Arbeit, R. W. Fuhrhop, K. D. Wallace, T. Thomas, J. Smith, K. Agyem, G. M. Lanza, S. A. Wickline, J. E. McCarthy, M. V. Wickerhauser

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In an earlier studies we reported on the application of Renyi entropy, If (r), r < 2, for the detection of precancerous lesions, by detection subtle changes in backscattered waveforms f(t) that occured as targeted nanoparticles slowly accumulated near the lesion. In contrast, the signal energy, defined as the sum of squares of the over the same moving window, was unable to detect this change (as was conventional B-mode imaging). Although the computational effort to obtain the result precluded its clinical application with currently available equipment, the study raised the possibility of further sensitivity improvements by using values of r closer to the limiting value of 2, where If (r) approaches infinity. The current study demonstrates that by extracting the asymptotic form of If (r) as r → 2 there is no loss of sensitivity. However, the resulting algorithm is must faster than previous approaches and has an operation count that is suitable for implementation in a real-time imaging system.

Original language	English
Title of host publication	2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
DOIs	https://doi.org/10.1109/ULTSYM.2009.5441843
State	Published - Dec 1 2009
Event	2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy Duration: Sep 20 2009 → Sep 23 2009

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
ISSN (Print)	1051-0117

Conference

Conference	2009 IEEE International Ultrasonics Symposium, IUS 2009
Country/Territory	Italy
City	Rome
Period	09/20/09 → 09/23/09

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10.1109/ULTSYM.2009.5441843

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Hughes, M. S., Marsh, J. N., Arbeit, J. M., Fuhrhop, R. W., Wallace, K. D., Thomas, T., Smith, J., Agyem, K., Lanza, G. M., Wickline, S. A., McCarthy, J. E., & Wickerhauser, M. V. (2009). Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009 [5441843] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2009.5441843

Hughes, M. S. ; Marsh, J. N. ; Arbeit, J. M. ; Fuhrhop, R. W. ; Wallace, K. D. ; Thomas, T. ; Smith, J. ; Agyem, K. ; Lanza, G. M. ; Wickline, S. A. ; McCarthy, J. E. ; Wickerhauser, M. V. / Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture. 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. 2009. (Proceedings - IEEE Ultrasonics Symposium).

@inproceedings{8e44fa87e52c4a62bad839cc9a9fd8a9,

title = "Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture",

abstract = "In an earlier studies we reported on the application of Renyi entropy, If (r), r < 2, for the detection of precancerous lesions, by detection subtle changes in backscattered waveforms f(t) that occured as targeted nanoparticles slowly accumulated near the lesion. In contrast, the signal energy, defined as the sum of squares of the over the same moving window, was unable to detect this change (as was conventional B-mode imaging). Although the computational effort to obtain the result precluded its clinical application with currently available equipment, the study raised the possibility of further sensitivity improvements by using values of r closer to the limiting value of 2, where If (r) approaches infinity. The current study demonstrates that by extracting the asymptotic form of If (r) as r → 2 there is no loss of sensitivity. However, the resulting algorithm is must faster than previous approaches and has an operation count that is suitable for implementation in a real-time imaging system.",

author = "Hughes, {M. S.} and Marsh, {J. N.} and Arbeit, {J. M.} and Fuhrhop, {R. W.} and Wallace, {K. D.} and T. Thomas and J. Smith and K. Agyem and Lanza, {G. M.} and Wickline, {S. A.} and McCarthy, {J. E.} and Wickerhauser, {M. V.}",

year = "2009",

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doi = "10.1109/ULTSYM.2009.5441843",

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Hughes, MS, Marsh, JN, Arbeit, JM, Fuhrhop, RW, Wallace, KD, Thomas, T, Smith, J, Agyem, K, Lanza, GM, Wickline, SA, McCarthy, JE & Wickerhauser, MV 2009, Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture. in 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009., 5441843, Proceedings - IEEE Ultrasonics Symposium, 2009 IEEE International Ultrasonics Symposium, IUS 2009, Rome, Italy, 09/20/09. https://doi.org/10.1109/ULTSYM.2009.5441843

Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture. / Hughes, M. S.; Marsh, J. N.; Arbeit, J. M.; Fuhrhop, R. W.; Wallace, K. D.; Thomas, T.; Smith, J.; Agyem, K.; Lanza, G. M.; Wickline, S. A.; McCarthy, J. E.; Wickerhauser, M. V.

2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. 2009. 5441843 (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Marsh, J. N.

AU - Arbeit, J. M.

AU - Fuhrhop, R. W.

AU - Wallace, K. D.

AU - Thomas, T.

AU - Smith, J.

AU - Agyem, K.

AU - Lanza, G. M.

AU - Wickline, S. A.

AU - McCarthy, J. E.

AU - Wickerhauser, M. V.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - In an earlier studies we reported on the application of Renyi entropy, If (r), r < 2, for the detection of precancerous lesions, by detection subtle changes in backscattered waveforms f(t) that occured as targeted nanoparticles slowly accumulated near the lesion. In contrast, the signal energy, defined as the sum of squares of the over the same moving window, was unable to detect this change (as was conventional B-mode imaging). Although the computational effort to obtain the result precluded its clinical application with currently available equipment, the study raised the possibility of further sensitivity improvements by using values of r closer to the limiting value of 2, where If (r) approaches infinity. The current study demonstrates that by extracting the asymptotic form of If (r) as r → 2 there is no loss of sensitivity. However, the resulting algorithm is must faster than previous approaches and has an operation count that is suitable for implementation in a real-time imaging system.

AB - In an earlier studies we reported on the application of Renyi entropy, If (r), r < 2, for the detection of precancerous lesions, by detection subtle changes in backscattered waveforms f(t) that occured as targeted nanoparticles slowly accumulated near the lesion. In contrast, the signal energy, defined as the sum of squares of the over the same moving window, was unable to detect this change (as was conventional B-mode imaging). Although the computational effort to obtain the result precluded its clinical application with currently available equipment, the study raised the possibility of further sensitivity improvements by using values of r closer to the limiting value of 2, where If (r) approaches infinity. The current study demonstrates that by extracting the asymptotic form of If (r) as r → 2 there is no loss of sensitivity. However, the resulting algorithm is must faster than previous approaches and has an operation count that is suitable for implementation in a real-time imaging system.

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T3 - Proceedings - IEEE Ultrasonics Symposium

BT - 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009

Y2 - 20 September 2009 through 23 September 2009

ER -

Hughes MS, Marsh JN, Arbeit JM, Fuhrhop RW, Wallace KD, Thomas T et al. Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. 2009. 5441843. (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2009.5441843

Real-time calculation of a limiting form of the renyi entropy for detection of subtle changes in scattering architecture

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