Readmission Following Gastric Cancer Resection: Risk Factors and Survival

Alexandra W. Acher, Malcolm H. Squires, Ryan C. Fields, George A. Poultsides, Carl Schmidt, Konstantinos I. Votanopoulos, Timothy M. Pawlik, Linda X. Jin, Aslam Ejaz, David A. Kooby, Mark Bloomston, David Worhunsky, Edward A. Levine, Neil Saunders, Emily Winslow, Clifford S. Cho, Glen Leverson, Shishir K. Maithel, Sharon M. Weber

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Abstract

Background: This study utilized a multi-institutional database to evaluate risk factors for readmission in patients undergoing curative gastrectomy for gastric adenocarcinoma with the intent of describing both perioperative risk factors and the relationship of readmission to survival. Methods: Patients who underwent curative resection of gastric adenocarcinoma from 2000 to 2012 from seven academic institutions of the US Gastric Cancer Collaborative were analyzed. In-hospital deaths and palliative surgeries were excluded, and readmission was defined as within 30 days of discharge. Univariate and multivariable logistic regression analyses were employed and survival analysis conducted. Results: Of the 855 patients, 121 patients (14.2 %) were readmitted. Univariate analysis identified advanced age (p < 0.0128), American Society of Anesthesiology status ≥3 (p = 0.0045), preexisting cardiac disease (p < 0.0001), hypertension (p = 0.0142), history of smoking (p = 0.0254), increased preoperative blood urea nitrogen (BUN; p = 0.0426), concomitant pancreatectomy (p = 0.0056), increased operation time (p = 0.0384), estimated blood loss (p = 0.0196), 25th percentile length of stay (<7 days, p = 0.0166), 75th percentile length of stay (>12 days, p = 0.0256), postoperative complication (p < 0.0001), and total gastrectomy (p = 0.0167) as risk factors for readmission. Multivariable analysis identified cardiac disease (odds ratio (OR) 2.4, 95 % confidence interval (CI) 1.6–3.3, p < 0.0001), postoperative complication (OR 2.3, 95 % CI 1.6–5.4, p < 0.0001), and pancreatectomy (OR 2.2, 95 % CI 1.1–4.1, p = 0.0202) as independent risk factors for readmission. There was an association of decreased overall median survival in readmitted patients (39 months for readmitted vs. 103 months for non-readmitted). This was due to decreased survival in readmitted stage 1 (p = 0.0039), while there was no difference in survival for other stages. Stage I readmitted patients had a higher incidence of cardiac disease than stage I non-readmitted patients (58 vs. 24 %, respectively, p = 0.0002). Conclusions: Within this multi-institutional study investigating readmission in patients undergoing curative resection for gastric cancer, cardiac disease, postoperative complication, and concomitant pancreatectomy were identified as significant risk factors for readmission. Readmission was associated with decreased overall median survival, but on further analysis, this was driven by differences in survival for stage I disease only.

Original languageEnglish
Pages (from-to)1284-1294
Number of pages11
JournalJournal of Gastrointestinal Surgery
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2016

Keywords

  • Adenocarcinoma
  • Gastrectomy
  • Gastric cancer
  • Readmission
  • Risk factors
  • Survival

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    Acher, A. W., Squires, M. H., Fields, R. C., Poultsides, G. A., Schmidt, C., Votanopoulos, K. I., Pawlik, T. M., Jin, L. X., Ejaz, A., Kooby, D. A., Bloomston, M., Worhunsky, D., Levine, E. A., Saunders, N., Winslow, E., Cho, C. S., Leverson, G., Maithel, S. K., & Weber, S. M. (2016). Readmission Following Gastric Cancer Resection: Risk Factors and Survival. Journal of Gastrointestinal Surgery, 20(7), 1284-1294. https://doi.org/10.1007/s11605-015-3070-2