TY - JOUR
T1 - Reactive oxygen species and glutathione
T2 - potential for parenteral nutrition supplementation?
AU - Fuhrman, M. Patricia
AU - Herrmann, Virginia M.
AU - Smith, Gregory S.
PY - 1999
Y1 - 1999
N2 - Glutathione has been implicated as an important antioxidant in the body's defense against the accumulation of reactive oxygen species (ROS). In critically ill patients, the balance between the production of ROS and the availability of antioxidants may shift to favor proliferation of ROS. This in turn may lead to significant tissue injury. Parenteral nutrition (PN) is a feeding modality often required by critically ill patients. PN solutions do not contain the components needed for endogenous glutathione synthesis and, thus, may reduce antioxidant availability and accentuate ROS damage. Supplementation of PN with nutrients that promote glutathione synthesis may attenuate ROS-induced cell destruction.
AB - Glutathione has been implicated as an important antioxidant in the body's defense against the accumulation of reactive oxygen species (ROS). In critically ill patients, the balance between the production of ROS and the availability of antioxidants may shift to favor proliferation of ROS. This in turn may lead to significant tissue injury. Parenteral nutrition (PN) is a feeding modality often required by critically ill patients. PN solutions do not contain the components needed for endogenous glutathione synthesis and, thus, may reduce antioxidant availability and accentuate ROS damage. Supplementation of PN with nutrients that promote glutathione synthesis may attenuate ROS-induced cell destruction.
UR - http://www.scopus.com/inward/record.url?scp=0042642914&partnerID=8YFLogxK
U2 - 10.1177/088453369901400508
DO - 10.1177/088453369901400508
M3 - Article
AN - SCOPUS:0042642914
SN - 0884-5336
VL - 14
SP - 254
EP - 263
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
IS - 5
ER -