Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

Willy Carrasquel-Ursulaez, Ryan D. Reeves, Mahzad Dehghany, Corey Jones, Jennifer M. Schomaker, Baron Chanda

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.

Original languageEnglish
Pages (from-to)40391-40394
Number of pages4
JournalRSC Advances
Volume10
Issue number66
DOIs
StatePublished - Nov 2020

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