@article{006e64ffa7bf4320973e8b2b67bea2af,
title = "Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds",
abstract = "The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.",
author = "Willy Carrasquel-Ursulaez and Reeves, {Ryan D.} and Mahzad Dehghany and Corey Jones and Schomaker, {Jennifer M.} and Baron Chanda",
note = "Funding Information: The NMR and Mass Spectrometry facilities are funded by the NSF (CHE-1048642, CHE-0342998, CHE-9304546 and CHE-9208463), the UW-Madison as well as a generous gi by Paul J. and Margaret M. Bender. We thank Prof. A Prindle and Peter Tran (Northwestern University) for generously sharing B. subtilis strains. We are grateful to Dr Jiang, Dr Chowdhury and Dr Cowgill for their generous help and training. This work was supported by funding from the UW2020 competition and the NIGMS award 5R21GM131662 (B. C. and J. M. S.) and NINDS award R35NS116850 (B. C.). Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",
year = "2020",
month = nov,
doi = "10.1039/d0ra08494h",
language = "English",
volume = "10",
pages = "40391--40394",
journal = "RSC Advances",
issn = "2046-2069",
number = "66",
}