Rational Design of Soft–Hard Interfaces through Bioinspired Engineering

Hui Zhang, Yufei Ma, Yijie Wang, Lin Niu, Rui Zou, Min Zhang, Hao Liu, Guy M. Genin, Ang Li, Feng Xu

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Soft–hard tissue interfaces in nature present a diversity of hierarchical transitions in composition and structure to address the challenge of stress concentrations that would otherwise arise at their interface. The translation of these into engineered materials holds promise for improved function of biomedical interfaces. Here, soft–hard tissue interfaces found in the body in health and disease, and the application of the diverse, functionally graded, and hierarchical structures that they present to bioinspired engineering materials are reviewed. A range of such bioinspired engineering materials and associated manufacturing technologies that are on the horizon in interfacial tissue engineering, hydrogel bioadhesion at the interfaces, and healthcare and medical devices are described.

Original languageEnglish
Article number2204498
Issue number1
StatePublished - Jan 4 2023


  • bioinspired materials
  • gradients
  • hierarchical structures
  • interfacial microenvironments


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