TY - JOUR
T1 - Rat serum albumin biosynthesis
T2 - Evidence for a precursor
AU - Russell, John H.
AU - Geller, David M.
N1 - Funding Information:
We thank Professor Ralph Bradshaw for allowing us to use the facilities of his laboratory for amino acid analyses. This project was supported by a General Research Support Grant made to Washington University from the National Institutes of Health and a Washington University Institutional Grant from the American Cancer Society. J.H.R. was supported by N.I.H. Training Grant 5T01-GM0096.
PY - 1973/11/1
Y1 - 1973/11/1
N2 - An albumin-like protein (pro-albumin) has been isolated from rat liver microsomal albumin by isoelectric focusing. Unlike intracellular serum albumin, it becomes highly radioactive in the course of albumin biosynthesis at the expense of labeled amino acids in vivo. The albumin-like protein is immunologically indistinguishable from rat serum albumin and has the same (or similar) N-terminus: glutamate (or glutamine). Maps of tryptic peptides suggest that the albumin-like protein may be a peptide derivative of serum albumin.
AB - An albumin-like protein (pro-albumin) has been isolated from rat liver microsomal albumin by isoelectric focusing. Unlike intracellular serum albumin, it becomes highly radioactive in the course of albumin biosynthesis at the expense of labeled amino acids in vivo. The albumin-like protein is immunologically indistinguishable from rat serum albumin and has the same (or similar) N-terminus: glutamate (or glutamine). Maps of tryptic peptides suggest that the albumin-like protein may be a peptide derivative of serum albumin.
UR - http://www.scopus.com/inward/record.url?scp=0015900803&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(73)80085-3
DO - 10.1016/S0006-291X(73)80085-3
M3 - Article
C2 - 4205910
AN - SCOPUS:0015900803
SN - 0006-291X
VL - 55
SP - 239
EP - 245
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -