Rat serum albumin biosynthesis: Evidence for a precursor

John H. Russell, David M. Geller

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


An albumin-like protein (pro-albumin) has been isolated from rat liver microsomal albumin by isoelectric focusing. Unlike intracellular serum albumin, it becomes highly radioactive in the course of albumin biosynthesis at the expense of labeled amino acids in vivo. The albumin-like protein is immunologically indistinguishable from rat serum albumin and has the same (or similar) N-terminus: glutamate (or glutamine). Maps of tryptic peptides suggest that the albumin-like protein may be a peptide derivative of serum albumin.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Nov 1 1973


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