Rat pro-opiomelanocortin contains sulfate

Harumi Hoshina, Glen Hortin, Irving Boime

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Intermediate lobes isolated from rat pituitary glands incorporated [ 35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.

Original languageEnglish
Pages (from-to)63-64
Number of pages2
JournalScience
Volume217
Issue number4554
DOIs
StatePublished - 1982

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