Rat brains also have a default mode network

Hanbing Lu, Qihong Zou, Hong Gu, Marcus E. Raichle, Elliot A. Stein, Yihong Yang

Research output: Contribution to journalArticlepeer-review

429 Scopus citations


The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function (s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.

Original languageEnglish
Pages (from-to)3979-3984
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number10
StatePublished - Mar 6 2012


  • Connectivity
  • Functional MRI
  • Intrinsic activity
  • Resting state
  • Spontaneous fluctuation


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