Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for benign and malignant tumor formation caused by germline mutations in the NF1 gene. With the cloning of the NF1 gene and the recognition that the encoded protein, neurofibromin, largely functions as a negative regulator of RAS activity, attention has mainly focused on RAS and canonical RAS effector pathway signaling relevant to disease pathogenesis and treatment. However, as neurofibromin is a large cytoplasmic protein the RAS regulatory domain of which occupies only 10% of its entire coding sequence, both canonical and non-canonical RAS pathway modulation, as well as the existence of potential non-RAS functions, are becoming apparent. In this Special article, we discuss our current understanding of neurofibromin function.

Original languageEnglish
Article numberdmm049362
JournalDMM Disease Models and Mechanisms
Issue number2
StatePublished - Feb 2022


  • Cyclic AMP
  • Neurofibromin
  • RAS
  • Tumor suppressor


Dive into the research topics of 'RAS and beyond: the many faces of the neurofibromatosis type 1 protein'. Together they form a unique fingerprint.

Cite this