Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence

Keyphrases

• Risk Reduction 100%
• Missense Variants 100%
• Nicotine Dependence 100%
• CHRNB4 100%
• Confidence Interval 40%
• Odds Ratio 40%
• African American 40%
• European American 40%
• Smokers 40%
• Nicotine 40%
• CHRNA5 40%
• CHRNB3 40%
• CHRNA6 40%
• CHRNA3 40%
• Genome-wide Association Study 20%
• Low Risk 20%
• Between-group 20%
• Minor Allele 20%
• Conserved Sites 20%
• Receptor Activity 20%
• Polymorphism 20%
• Coding Region 20%
• Linkage Disequilibrium 20%
• Allele Frequency 20%
• Cellular Response 20%
• Functional Impact 20%
• Conserved Residues 20%
• Flanking Sequence 20%
• Non-carriers 20%
• Gene Cluster 20%
• Nicotinic Receptor Genes 20%
• Cigarettes per Day 20%
• Rare Variation 20%
• Common Variation 20%
• Rare Allele 20%
• Carrier Status 20%
• Pooled Sequencing 20%

Neuroscience

• Tobacco Dependence 100%
• CHRNB4 100%
• CHRNA3 66%
• In Vitro 33%
• CHRNA5 33%
• Receptor Gene 16%
• DNA Flanking Region 16%
• Genome-Wide Association Study 16%
• Allele Frequency 16%
• Coding Region 16%
• Linkage Disequilibrium 16%
• Nicotinic Receptor 16%
• Gene Cluster 16%
• Receptor 16%

Biochemistry, Genetics and Molecular Biology

• Missense 100%
• CHRNB4 100%
• CHRNA3 66%
• Smoking 33%
• CHRNA5 33%
• Gene Frequency 16%
• Allele 16%
• Genome-Wide Association Study 16%
• Receptor Gene 16%
• Gene Cluster 16%
• Coding Region 16%
• Gene Linkage Disequilibrium 16%
• DNA Flanking Region 16%
• Nicotinic Receptor 16%