Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease

Keyphrases

• Alzheimer's Disease 100%
• APOE4 100%
• Rare Genetic Variation 100%
• Fibronectin 1 100%
• APOE4 Carriers 45%
• Extracellular Matrix 27%
• Loss Function 18%
• Gain-of-function mutation 18%
• Blood-brain Barrier 18%
• Aging 18%
• Alzheimer's Disease Risk 18%
• Alzheimer's Disease Pathology 18%
• Collagen Type VI 18%
• Microglial Response 9%
• Protein Level 9%
• Therapeutic Intervention 9%
• Path Analysis 9%
• Age of Onset 9%
• Protective Effect 9%
• Large Cohort 9%
• Healthy Individuals 9%
• Dementia 9%
• Family Study 9%
• Orthologs 9%
• Cellular Mechanisms 9%
• Pathogenicity 9%
• APOE ε4 Allele 9%
• Fibronectin 9%
• Cognitive Decline 9%
• Extracellular Matrix Protein 1 (ECM1) 9%
• Genetic Variation 9%
• Functional Studies 9%
• Potential Therapeutics 9%
• Rare Coding Variants 9%
• Alzheimer 9%
• Protein Clearance 9%
• Whole-genome Sequence Data 9%
• Zebrafish Model 9%
• Toxic Protein 9%
• Intervention Targets 9%
• Gene Ontology Terms 9%
• Unaffected Carrier 9%
• Pathological Effect 9%
• Reactive Gliosis 9%
• Cognitively Healthy 9%
• Gliosis 9%
• Protective Variants 9%
• 70 Years Old 9%
• Functional Modification 9%
• Brain Expression 9%
• Washington Heights 9%
• Columbia 9%

Neuroscience

• Alzheimer's Disease 100%
• Genetic Variation 100%
• Fibronectin 100%
• Extracellular Matrix 25%
• Gliosis 16%
• Collagen Type 6 16%
• Blood Brain Barrier 16%
• In Vivo 8%
• Whole Genome Sequencing 8%
• Loss of Function Mutation 8%
• Extracellular Matrix Proteins 8%

Biochemistry, Genetics and Molecular Biology

• Genetic Divergence 100%
• Genetic Variation 100%
• Fibronectin 100%
• Blood Brain Barrier 16%
• Gliosis 16%
• Allele 8%
• Gene Ontology 8%
• Whole Genome Sequencing 8%
• Loss of Function Mutation 8%
• Orthology 8%
• Zebra Fish 8%
• Extracellular Matrix Proteins 8%
• Scleroprotein 8%