@article{fdaa5873ce694461bb1866019adcb1e6,
title = "Rapidly Customizable, Scalable 3D-Printed Wireless Optogenetic Probes for Versatile Applications in Neuroscience",
abstract = "Optogenetics is an advanced neuroscience technique that enables the dissection of neural circuitry with high spatiotemporal precision. Recent advances in materials and microfabrication techniques have enabled minimally invasive and biocompatible optical neural probes, thereby facilitating in vivo optogenetic research. However, conventional fabrication techniques rely on cleanroom facilities, which are not easily accessible and are expensive to use, making the overall manufacturing process inconvenient and costly. Moreover, the inherent time-consuming nature of current fabrication procedures impede the rapid customization of neural probes in between in vivo studies. Here, a new technique stemming from 3D printing technology for the low-cost, mass production of rapidly customizable optogenetic neural probes is introduced. The 3D printing production process, on-the-fly design versatility, and biocompatibility of 3D printed optogenetic probes as well as their functional capabilities for wireless in vivo optogenetics is detailed. Successful in vivo studies with 3D printed devices highlight the reliability of this easily accessible and flexible manufacturing approach that, with advances in printing technology, can foreshadow its widespread applications in low-cost bioelectronics in the future.",
keywords = "3D printing, microfabrication, neural probes, optogenetics, wireless probes",
author = "Juhyun Lee and Parker, {Kyle E.} and Chinatsu Kawakami and Kim, {Jenny R.} and Raza Qazi and Junwoo Yea and Shun Zhang and Kim, {Choong Yeon} and John Bilbily and Jianliang Xiao and Jang, {Kyung In} and McCall, {Jordan G.} and Jeong, {Jae Woong}",
note = "Funding Information: J.L., K.E.P., C.K., and J.R.K. authors contributed equally to this work. The authors thank Prof. Daesoo Kim's lab at KAIST for explanted tissue. This paper is based on research which has been conducted as part of the KAIST‐funded Global Singularity Research Program for 2020. This work was also supported by the National Research Foundation of Korea (grant nos. NRF‐2018R1C1B6001706 and NRF‐2017M3A9G8084463, J.‐W.J.), the Brain & Behavior Research Foundation (NARSAD YI ‐ 28565, J.G.M.), and the United States National Institutes of Health (R25 MH112473, J.B.). Funding Information: J.L., K.E.P., C.K., and J.R.K. authors contributed equally to this work. The authors thank Prof. Daesoo Kim's lab at KAIST for explanted tissue. This paper is based on research which has been conducted as part of the KAIST-funded Global Singularity Research Program for 2020. This work was also supported by the National Research Foundation of Korea (grant nos. NRF-2018R1C1B6001706 and NRF-2017M3A9G8084463, J.-W.J.), the Brain & Behavior Research Foundation (NARSAD YI - 28565, J.G.M.), and the United States National Institutes of Health (R25 MH112473, J.B.). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",
year = "2020",
month = nov,
day = "11",
doi = "10.1002/adfm.202004285",
language = "English",
volume = "30",
journal = "Advanced Functional Materials",
issn = "1616-301X",
number = "46",
}