Rapid quantitative pharmacodynamic imaging with Bayesian Estimation

Jonathan M. Koller, M. Jonathan Vachon, G. Larry Bretthorst, Kevin J. Black

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We recently described rapid quantitative pharmacodynamic imaging, a novel method for estimating sensitivity of a biological system to a drug. We tested its accuracy in simulated biological signals with varying receptor sensitivity and varying levels of random noise, and presented initial proof-of-concept data from functional MRI (fMRI) studies in primate brain. However, the initial simulation testing used a simple iterative approach to estimate pharmacokinetic-pharmacodynamic (PKPD) parameters, an approach that was computationally efficient but returned parameters only from a small, discrete set of values chosen a priori. Here we revisit the simulation testing using a Bayesian method to estimate the PKPD parameters. This improved accuracy compared to our previous method, and noise without intentional signal was never interpreted as signal. We also reanalyze the fMRI proof-of-concept data. The success with the simulated data, and with the limited fMRI data, is a necessary first step toward further testing of rapid quantitative pharmacodynamic imaging.

Original languageEnglish
Pages (from-to)1
Number of pages1
JournalFrontiers in Neuroscience
Volume10
Issue numberAPR
DOIs
StatePublished - Apr 8 2016

Keywords

  • Bayesian parameter estimation
  • PK-PD modeling
  • Pharmacodynamics
  • Pharmacological imaging

Fingerprint Dive into the research topics of 'Rapid quantitative pharmacodynamic imaging with Bayesian Estimation'. Together they form a unique fingerprint.

Cite this