Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice

Lawrence G. Miller, Michael L. Thompson, David J. Greenblatt, Stephen I. Deutsch, Richard I. Shader, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine receptor binding is observed in the cerebral cortex, cerebellum and hypothalamus, and appears to be due to an increase in receptor number rather than apparent affinity. the stress-induced in central benzodiazepine receptors is decreased in a dose-dependent fashion by lorazepam, a benzodiazepine agonist, but not by the receptor antagonist Ro15-1788. The stress-induced increase in benzodiazepine receptors is also blocked by adrenalectomy and is restored by corticosterone replacement.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalBrain Research
Volume414
Issue number2
DOIs
StatePublished - Jun 30 1987

Keywords

  • Adrenal steroid
  • Benzodiazepine
  • Benzodiazepine receptor
  • Stress

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