TY - JOUR
T1 - Rapid diagnosis of myocardial infarction and reperfusion by assay of plasma isoforms of creatine kinase isoenzymes
AU - Abendschein, Dana R.
N1 - Funding Information:
This research was supported by grants HL-36274 and
PY - 1990/10
Y1 - 1990/10
N2 - Early, reliable detection of acute myocardial infarction and of coronary artery recanalization, in patients receiving thrombolytic agents, is essential to guide the course of therapy. Because the MM and MB isoenzymes of creatine kinase (CK) released from myocardium, undergo time-dependent removal of carboxyl terminal lysine residues from each monomer during exposure to circulating carboxypeptidase N, plasma profiles of the resulting isoforms are altered promptly and markedly after the release of new tissue isoenzymes. This paper reviews the results of experimental and preliminary clinical studies, showing the potential for rapid diagnosis of myocardial infarction and coronary artery recanalization by analysis of isoforms of CK isoenzymes in plasma.
AB - Early, reliable detection of acute myocardial infarction and of coronary artery recanalization, in patients receiving thrombolytic agents, is essential to guide the course of therapy. Because the MM and MB isoenzymes of creatine kinase (CK) released from myocardium, undergo time-dependent removal of carboxyl terminal lysine residues from each monomer during exposure to circulating carboxypeptidase N, plasma profiles of the resulting isoforms are altered promptly and markedly after the release of new tissue isoenzymes. This paper reviews the results of experimental and preliminary clinical studies, showing the potential for rapid diagnosis of myocardial infarction and coronary artery recanalization by analysis of isoforms of CK isoenzymes in plasma.
KW - coronary artery recanalization
KW - creatine kinase isoenzymes
KW - myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=0025155339&partnerID=8YFLogxK
U2 - 10.1016/0009-9120(90)90136-I
DO - 10.1016/0009-9120(90)90136-I
M3 - Article
C2 - 2253334
AN - SCOPUS:0025155339
SN - 0009-9120
VL - 23
SP - 399
EP - 407
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 5
ER -