Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells

Silvia Jansen, Maria Andries, Katrien Vekemans, Hubert Vanbilloen, Alfons Verbruggen, Mathieu Bollen

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2), is a secreted lysophospholipase-D that generates lysophosphatidic acid and thereby promotes the metastatic and invasive properties of tumor cell as well as angiogenesis. We show here that, in mice, NPP2 is cleared from the circulation within minutes and is retained by the liver sinusoidal endothelial cells (LSECs). The binding of NPP2 to isolated LSECs resulted in its degradation and could be competed for with ligands of the scavenger receptor family. Our finding that circulating NPP2 has a rapid turnover has important implications for its development as an anti-cancer target.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalCancer Letters
Volume284
Issue number2
DOIs
StatePublished - Nov 1 2009

Keywords

  • Autotaxin
  • Liver sinusoidal endothelial cells
  • Lysophospholipase-D
  • Metastasis
  • Scavenger receptor

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