Rapid calcium-current kinetics in synaptic terminals of goldfish retinal bipolar neurons

Steven Mennerick, Gary Matthews

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Onset and offset of calcium current in response to short, depolarizing voltage pulses were studied in giant synaptic terminals of goldfish bipolar neurons. Tail-current decays were extremely rapid (80/μs at -70 mV), and exponentially slowed at more positive repolarization potentials. The amplitude of tail current following voltage pulses varied with the pulse amplitude, according to a Bolzmann distribution with a V(1/2) of -27.6 mV and a slope factor of 13.8 mV. When interpreted with a Hodgkin-Huxley model, calcium-current onset was best described by m2 kinetics and a time constant (τ(m)) of 0.62 ms at -10 mV. The kinetics of calcium-current onset and offset are at least two- to threefold faster than those described in other native cells. Combined with other recent data, the results suggest that the rapid kinetics may participate in a fast signaling mode in the goldfish ON-center pathway.

Original languageEnglish
Pages (from-to)1051-1056
Number of pages6
JournalVisual Neuroscience
Volume15
Issue number6
DOIs
StatePublished - Nov 1 1998

Keywords

  • Activation
  • Calcium channel
  • Neurotransmitter
  • Presynaptic
  • Retina

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