Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

Keyphrases

• Apoptosis 100%
• Ischemic Penumbra 100%
• Rapamycin 100%
• Ischemia-reperfusion Injury 100%
• Penumbra 100%
• Autophagy 100%
• Cerebral Stroke 100%
• MTOR Pathway 80%
• Mammalian Target of Rapamycin (mTOR) 60%
• Neurological Function 60%
• Infarct Volume 60%
• Ischemic Core 60%
• Signaling Pathway 40%
• ULK1 40%
• Beclin-1 40%
• Cleaved caspase-9 40%
• Overactivation 20%
• Protein Expression 20%
• Ischemia 20%
• Cell Apoptosis 20%
• Caspase-3 20%
• Western Blot Analysis 20%
• Neuronal Apoptosis 20%
• Ischemic Injury 20%
• Activation Volume 20%
• MTOR Inhibitor 20%
• Autophagy-related Proteins 20%
• Transient Middle Cerebral Artery Occlusion (tMCAO) 20%
• Neuron Activation 20%
• LC3-II 20%
• Fluoro-Jade B 20%
• Cleaved caspase-3 20%
• Apoptosis-related Proteins 20%
• TTC Staining 20%
• Modified Neurological Severity Score 20%

Neuroscience

• Autophagy 100%
• Cerebrovascular Accident 100%
• Sirolimus 100%
• Programmed Cell Death 100%
• Staining Technique 50%
• Cell Signaling 50%
• Caspase 3 50%
• Beclin 1 50%
• Caspase-9 50%
• Protein Expression 25%
• Western Blot 25%
• Neuroapoptosis 25%
• Middle Cerebral Artery 25%
• Autophagy Related Protein 25%
• Ischemia 25%